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Increasing Resolution in Perfusion Magnetic Resonance Imaging Using Compressed Sensing
Mangová, Marie ; Polec,, Jaroslav (referee) ; Šmídl, Václav (referee) ; Rajmic, Pavel (advisor)
Perfusion magnetic resonance imaging is a medical diagnostic method which requires high spatial and temporal resolution simultaneously to capture dynamics of an intravenous contrast agent which is used to perfusion measurement. However, magnetic resonance imaging has physical limits which do not allow to have this resolution simultaneously. This thesis deals with compressed sensing which enables to reconstruct measured data from relatively few acquired samples (below Nyquist rate) while resolution required to perfusion analysis is increased. This aim could be achieved with suitably proposed apriory information about sensed data and model proposal. The reconstruction is then done as an optimization problem. Doctoral thesis brings several new reconstruction models, further proposes method to debias this estimates and examines influence of compressed sensing onto perfusion parameters. Whole thesis is ended with extension of compressed sensing into three-dimensional data. Here, the influence of reconstruction onto perfusion parameters is also described. In summary, the thesis shows that due to compressed sensing, temporal resolution can be increased with the fixed spatial resolution or spatial resolution can be increased with the fixed temporal resolution.
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Pacemakers and electromagnetic interference
Lojková, Lea ; Sekora, Jiří (referee) ; Havlíková, Marie (advisor)
This work is focused on cardiac pacemakers and sources of electronic interference. The project partly follows another thesis made in the same field of interest (Ing. Kulík, Dept. of Control, Measurement and Instrumentation) and uses similar methodics of measurement. In the theoretical part of the work, the principles of nuclear magnetic resonance and magnetic resonance imaging are briefly explained and most common methods used in MRI are described, as well as the definition of a cardiac pacemaker, main events in pacemaker history and development. Cardiac pacemaker as a system is described in more detail, including construction, control, most common sensors and the ways of use. Electromagnetic interference of cardiac pacemakers and implantable cardioverter defibrillators is processed via a complete review since the oldest scientific paper from December 1991 till May 2009. In the second part, measuring of magnetic field is described, as well as the possibilities of monitoring of its effects on cardiac pacemakers. In fact, there are two possible ways of measuring. off-line exposition of the sample to the magnetic field followed by data acquisition via pacemaker programmer or the continuous on-line monitoring of the pacemaker activity by the means of measuring PC card. While the first method is reliable in cases where the is no sign of malfunction and makes the experiments with a dynamic exposition of sample possible, in some cases it detects a virtual malfunction also in cases where in reality the devices works perfectly. The second method enables a reliable continuous monitoring of pacemaker activity during the whole experiment and its only problem is a higher level of signal noise caused by the sample movement.
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Image segmentation of spinal disc in medical imaging
Meloun, Jan ; Nemček, Jakub (referee) ; Mézl, Martin (advisor)
This thesis is focused on segmentation of intervertebral discs in images from two medical imaging modalities - computed tomography (CT) and magnetic resonance imaging (MRI). Theoretical introduction of the thesis describes intervertebral disc herniation and relevant imaging modalities. It also includes description of basic and advanced segmentation methods. For practical part of the thesis, three different segmentation teqniques (one for CT data and two for MRI images) have been chosen, implemented and applied on images acquired at Radiodiagnostic department of Havlíčkův Brod hospital. The segmentation quality has been assessed quantitatively for individual methods by comparing the segmentation results to manually created reference segmentation of intervertebral discs.
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Implementation of Dixon Methods for Preclinical MR Imaging at High Fields
Kořínek, Radim ; Latta,, Peter (referee) ; Puková,, Andrea Šprláková - (referee) ; Bartušek, Karel (advisor)
Preklinické magneticko-rezonanční (MR) zobrazování na malých zvířatech je velmi aktuální a vyžaduje, vzhledem k rozměrům těchto zvířat, vyšší citlivost. Vyšší citlivosti lze dosáhnout použitím MR systému s vysokým základním magnetickým polem (např. 4,7 T a výše). Vyšší citlivost přináší výhody v podobě možnosti vyššího rozlišení, lepší poměr signál-šum, větší chemický posuv, prodloužení longitudinální relaxace (T1), atd. Na druhou stranu vyšší magnetické pole znamená větší deformace základního magnetického pole na rozhraních tkání s rozdílnou susceptibilitou a zkrácení transverzální relaxace (T2). Tuková tkáň je významně zastoupena v lidském těle a primárně sloužící pro uchovávání energie ve formě tuků. Tukovou tkáň lze rozdělit na hnědou a bílou tukovou tkáň. Hnědá tuková tkáň se vyskytuje hlavně u novorozenců, ale může být ve velmi malém množství také u dospělých jedinců. Bílá tuková tkáň je určena pro ukládání tuků, které slouží jako zdroj energie. Kromě toho bílá tuková tkáň produkuje adipokiny, hormony a mnoho dalších látek důležitých pro náš metabolizmus. Tuk lze obecně považovat jako biomarker při určitých nemocech (obezita, steatóza jater, a další). Z tohoto důvodu je kvantifikace tuku velmi důležitá pro správnou diagnózu. V MR zobrazování je speciální skupina metod pro separaci vody a tuku. Tyto metody se nazývají Dixonovy metody a jejich princip je založen na chemickém posuvu. V této práci je popsána nová T2-váhovaná sekvence pro Dixonovu akvizici (Kapitola 5.3). Navržená sekvence je z hlediska akviziční doby velmi efektivní a řadí se mezi tříbodové Dixonovy (3PD) techniky. Nově navržená sekvence fast triple spin echo Dixon (FTSED) vychází z původní sekvence rychlého spinového echa (FSE). Modifikací původní sekvence FSE vedla ke vzniku nové sekvence FTSED, která umožňuje získat tři obrazy během jediné akvizice, bez toho aniž bychom prodloužili celkovou dobu měření. Sekvence byla úspěšně implementována na 9,4 T MRI systém na Ústavu přístrojové techniky v Brně. Získaná data byla pak zpracována iterativně pomocí algoritmu IDEAL (iterative decomposition of water and fat with echo asymmetry and least-squares estimation). Výsledkem jsou separátní obrazy vody a tuků, z kterých lze vypočítat mapy frakce tuku (FF-mapy). Sekvence byla ověřena na fantomech a poté byla odzkoušena potkanovi. Úspěšná implementace této metody na 9,4 T MRI systému znamená, že může být použita také na MR zobrazovacích systémech s nižšími magnetickými poli.
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Parallelization of complex tasks in reconstruction of dynamic magnetic resonance
Bijotová, Kateřina ; Rajmic, Pavel (referee) ; Mašek, Jan (advisor)
This thesis deals with parallelization of complex tasks in reconstruction of dynamic magnetic resonance. It describes the basic principle of magnetic resonance and its relation to Fourier transform. It deals with the difference between static and dynamic magnetic resonance image reconstruction. It analyzes SVD algorithm and its use in magnetic resonance image reconstruction. It presents the principles and the importance of parallel computing in magnetic resonance imaging and describes CUDA technology. The thesis also contains a description and execution of the implementation of the reconstruction model in MATLAB and Java programming language which were optimized by JCuda library for Java implementation and gpuArray function in case of MATLAB implementation.
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Parallelization of complex tasks in reconstruction of dynamic magnetic resonance
Bijotová, Kateřina ; Rajmic, Pavel (referee) ; Mašek, Jan (advisor)
This thesis deals with parallelization of complex tasks in reconstruction of dynamic magnetic resonance. It describes the basic principle of magnetic resonance and its relation to Fourier transform. It deals with the difference between static and dynamic magnetic resonance image reconstruction. It analyzes SVD algorithm and its use in magnetic resonance image reconstruction. It presents the principles and the importance of parallel computing in magnetic resonance imaging and describes CUDA technology. The thesis also contains a description and execution of the implementation of the reconstruction model in MATLAB and Java programming language which were optimized by JCuda library for Java implementation and gpuArray function in case of MATLAB implementation.
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Contrast agents for 19F magnetic resonance imaging
Dobrovolná, Tereza ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
Complexes of transition metal ions with ligands containing fluorine atoms represent an interesting group of 19 F MRI contrast agents that could facilitate the diagnosis of various diseases. The presence of a paramagnetic metal ion in the vicinity of the 19 F nucleus results in shorter relaxation times and the possibility to obtain more NMR spectra in a given time, leading to better resolution. This work deals with the synthesis of the fluorinated macrocyclic ligand H3NOTPtfe , the preparation of its complexes with transition metal ions, their characterization and study by methods suitable for assessing their applicability in 19 F MRI, i.e. relaxometric NMR measurements and electrochemistry. The results show that the chosen concept is promising for 19 F MRI. The prepared complexes are applicable as 19 F MRI contrast agents, some even as redox active 19 F MRI "smart" contrast agents. The best properties were observed for the complex [Co(NOTPtfe )]− . Keywords: heteronuclear MRI, contrast agent, fluorine, PRE effect, spin relaxation, magnetic resonance imaging, paramagnetic complexes
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Finding the proportion of levator and fascial trauma of the pelvic floor in the development of symptoms pelvic organ prolapse - the effect of vaginal birth
Horčička, Lukáš ; Krofta, Ladislav (advisor) ; Halaška, Michael (referee) ; Chmel, Roman (referee)
Determination of the proportion of levator and fascial trauma of the pelvic floor in the development of symptoms of the descent of pelvic organs - the influence of vaginal birth Abstract Injury of levator ani muscle (LAM) is a significant pelvic organ prolapse (POP) risk factor. The puborectalis (PRM) and pubvisceral (PVM) subdivisions are at Level III vaginal support structures. Null hypothesis - there were no significant differences in muscle injuries patterns among LAM subdivisions. This retrospective magnetic resonance imaging (MRI) study included: 64 nulligravidae controls without pelvic floor dysfunction (PFD) and 526 POP symptomatic women of different parity. Primary outcome was PVM and PRM morphology on axial planes 1/ the place of the attachment to the pubic bone, 2/ visible separation/border between PVM and PRM. The attachment was scored as "normal" or "abnormal". The "abnormal" was divided in two types: a) "Type I" - loss of the muscle substance, but maintenance of the overall muscle architecture, b) "Type II" - muscle detachment from the pubic bone. The puboanalis (PAM) subdivision was evaluated as representative part of PVM. PAM and PRM attachments and separation were distinguished in all control cases. PAM and PRM attachments did not significantly differ. POP group characteristics were:...
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Image segmentation of spinal disc in medical imaging
Meloun, Jan ; Nemček, Jakub (referee) ; Mézl, Martin (advisor)
This thesis is focused on segmentation of intervertebral discs in images from two medical imaging modalities - computed tomography (CT) and magnetic resonance imaging (MRI). Theoretical introduction of the thesis describes intervertebral disc herniation and relevant imaging modalities. It also includes description of basic and advanced segmentation methods. For practical part of the thesis, three different segmentation teqniques (one for CT data and two for MRI images) have been chosen, implemented and applied on images acquired at Radiodiagnostic department of Havlíčkův Brod hospital. The segmentation quality has been assessed quantitatively for individual methods by comparing the segmentation results to manually created reference segmentation of intervertebral discs.
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Structural Patterns of Cognitive Deficits in MR Imaging.
Buksakowska, Irena ; Hořínek, Daniel (advisor) ; Rulseh, Aaron (referee) ; Dušek, Petr (referee)
Structural and diffusion imaging patterns that can be evaluated using MRI in patients with cognitive deficits are the central theme of the proposed work. First, the clinical and neuroimaging background of dementias has been reviewed in a broader context, with a special focus on Alzheimer's disease (AD) and differential diagnoses. The second part of this thesis contains four consecutive experimental studies. The primary objective of the first two studies was to obtain structural and microstructural information on the neurodegenerative processes characteristic for AD on global and regional levels. For this purpose, several complementary approaches were used and the focus was shifted from grey to white matter (GM/WM). The following two studies focused on the differential context of WM microstructural alterations in normal pressure hydrocephalus (NPH) and distinctive patterns of WM disintegrity in temporal lobe epilepsy (TLE). The most important conclusion of our studies is that structural and diffusion imaging proved to be useful in identifying regionally specific and disproportionate loss of brain volume and microstructure in several pathological processes underlying cognitive deterioration. The use of distinctive morphometric methods yielded complementary information on AD-related atrophy patterns,...
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